Question about restoration of a wallet

MoneroMonero
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self.Monero
I have been looking at several guide and information at the getmonero website, but I am not sure if I am understanding this correctly. In the event my machine crashes, though I have a backup of my wallet file encrypted on my backup device, what is the proper procedure to restore using a hardware wallet? Am I supposed to use the Block # and Mnemonic seed? Or is this seed the same one I used when setting up my Ledger? I just need something in the case of disaster recovery. Once I understand it, I will understand it and restore it.